Lung reaeration after surfactant instillation - caused by surfactant or caused by instillation?
نویسندگان
چکیده
منابع مشابه
Lung reaeration after surfactant instillation - caused by surfactant or caused by instillation?
signifi cant and prolonged lung reaeration after intratracheal bolus instillation of porcine-derived surfactant. In this substudy of a larger randomized controlled trial of patients with acute lung injury [2], the investigators elegantly demonstrate increased volumes of gas in poorly and non-aerated lung of patients who were treated with surfactant as compared with patients who received routine...
متن کاملMeniscus formation during tracheal instillation of surfactant.
The method of surfactant instillation into the lungs for treatment of neonatal respiratory distress syndrome is an important attribute of delivery, and it may determine the overall efficacy of treatment. Previous studies primarily focused on the rate at which the bolus is instilled. These findings show that rapid injections lead to a more homogenous distribution, whereas slow infusions drain in...
متن کاملReactive pleural inflammation caused by intratracheal instillation of killed microbes.
To investigate the pleural leucocyte response to severe alveolar inflammation, heat-killed Corynebacterium parvum were instilled intratracheally into the lungs of PVG rats and pleural lavage was performed. Polymorphonuclear neutrophils are not normally resident in the pleural space but were found transiently after intratracheal instillation of C. parvum. Macrophages increased gradually in the p...
متن کاملEffects of intratracheal instillation of TNF-alpha on surfactant metabolism.
Tumor necrosis factor-alpha (TNF-alpha) has been shown to play an integral role in the pathogenesis of the acute respiratory distress syndrome. This disorder is characterized by a deficiency of alveolar surfactant, a surface-active material that is composed of key hydrophobic proteins and the major lipid disaturated phosphatidylcholine (DSPC). We investigated how TNF-alpha might alter DSPC cont...
متن کاملThalidomide-like malformations caused by Tween surfactant in mice.
The nonionic surfactant Tween 20 [polyoxyethylene(20)sorbitan monolaurate] is one of the more frequently encountered xenobiotics. Surface-active agents of the Tween type are used as constituents of cleaning agents, as food additives and as vehicles in the drug and cosmetic industry [1], Because of its good solubilizing properties Tween 20 has been used in teratological experiments as a solubili...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Critical Care
سال: 2010
ISSN: 1364-8535
DOI: 10.1186/cc9211